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Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

HIPEC is an advanced treatment providing hope for patients with abdominal cancer.

HIPEC Surgery at OSF Cancer Institute

When the diagnosis is abdominal cancer that has spread, you deserve to receive the best, most effective treatment. OSF HealthCare Cancer Institute is a leader in state-of-the-art cancer care, and we’re one of only two health care providers in Illinois outside of Chicago to offer hyperthermic intraperitoneal chemotherapy (HIPEC) surgery.

What is HIPEC surgery?

HIPEC surgery is a treatment option for certain patients with inoperable or advanced stages of abdominal cancer that has spread to the peritoneum (the lining of the abdominal cavity). In these cases, HIPEC is a more effective treatment than systemic chemotherapy (traditional chemotherapy delivered through an IV).

Cancers We Treat

HIPEC is most commonly used for treating the following types of abdominal cancer:

  • Adrenal cancer
  • Appendix cancer
  • Colon and rectal cancer
  • Gastric (stomach) cancer
  • Low-grade appendiceal mucinous neoplasm (LAMN)
  • Mesothelioma
  • Ovarian cancer
  • Peritoneal cancer

Studies are currently being conducted to determine if HIPEC can also be an effective treatment for pancreatic cancer.

How is the HIPEC procedure performed?

After you’re placed under anesthesia, HIPEC surgery will be performed in two stages over the course of four to 14 hours. The first stage is called cytoreductive surgery, and the second stage is the HIPEC operation.

Cytoreductive Surgery

During cytoreductive surgery, a surgeon will make an incision in your abdomen to view and remove all visible cancerous tumors and diseased tissue.

HIPEC Operation

During the HIPEC procedure, a surgeon inserts a catheter into the abdomen and temporarily sutures the abdomen shut. They then pump heated chemotherapy drugs into the abdominal cavity for one to two hours. During this time, the surgeon uses their hands to gently rock your body back and forth on the operating table. This ensures that the chemotherapy reaches all areas of the abdomen in order to destroy any remaining cancer cells. The surgeon then drains the chemotherapy from the abdomen and rinses the abdomen with a saline solution before the incision is permanently closed.

What are the benefits of HIPEC?

  • It can significantly improve cancer survival rates. However, your success depends on where the cancer started.
  • It allows chemotherapy to reach parts of the abdominal cavity that systemic chemotherapy can’t reach.
  • It makes it possible to administer larger doses of chemotherapy to more efficiently destroy any cancer cells that may remain after cytoreductive surgery.
  • The chemotherapy is heated to 107 degrees Fahrenheit, which makes it more effective in killing cancer cells.
  • It’s completed in one treatment as opposed to the multiple treatments needed for systemic chemotherapy.
  • It minimizes the exposure of chemotherapy to the rest of the body, which helps avoid chemotherapy’s typical side effects (hair loss, nausea, etc.).

What are the risks of HIPEC?

  • Like other surgeries, there’s a risk of bleeding and infection.
  • General anesthesia makes you unconscious during surgery so you don’t feel any pain. It’s generally very safe, but there are risks of minor side effects, such as nausea, vomiting, chills, confusion and sore throat. There are also risks of serious side effects, but they are rare and generally due to a patient’s age or certain medical conditions.
  • Removing tumors leaves internal wounds, and chemotherapy can make those wounds heal more slowly.
  • The procedure can cause kidney disease or injury to the kidneys.

What are the possible side effects of HIPEC surgery?

HIPEC side effects can include:

  • Bloating
  • Constipation
  • Depression
  • Diarrhea
  • Fatigue
  • Insomnia
  • Nausea and vomiting
  • Pain
  • Weight loss

What is recovery like after the HIPEC treatment?

Recovery after HIPEC depends on how long the surgery takes and how much cancer needs to be removed. After surgery, you may be in the hospital for one to two weeks before going home to continue recovering.

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Your Care Team

Our HIPEC team consists of a surgical oncologist (a surgeon), a medical oncologist, an advanced practice nurse and a cancer nurse navigator.

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